Lost volume, but don't want a filled-up face? Profhilo® Structura is the first product that specifically regenerates the facial fat tissue – for natural volume build-up from within.
The problem: facial ageing begins deeper than we think
When the face loses its freshness over the years, many people first think of wrinkles. But the real change begins deeper: the subcutaneous fat tissue – the natural padding that makes a young face look soft and voluminous – diminishes over time. Cheeks become flatter, contours sag, the face appears gaunt or tired.
Classic hyaluronic acid fillers can replace volume – but they only fill. They regenerate nothing. Profhilo® Structura takes a fundamentally different approach.
What is Profhilo® Structura?
Profhilo® Structura is a hybrid complex of highly concentrated hyaluronic acid – developed by IBSA Derma based on the patented NAHYCO® technology. It contains 90 mg of hyaluronic acid per 2 ml (45 mg high-molecular + 45 mg low-molecular) – considerably more concentrated than classic HA products.
The decisive point: Profhilo® Structura is not injected into the skin, but deep into the fat compartments of the face – precisely where the age-related loss of fat tissue has occurred. The result is a natural lifting effect and a genuine regeneration of the fat tissue.
Clinically proven: what studies show
In a clinical pilot study (Sparavigna et al. 2024) with 50 participants, an increase in tissue thickness of 23 % was measured after treatment with Profhilo® Structura – still three months after the first treatment. 95 % of patients reported a visible improvement already after the first session.
No serious side effects were observed. Tolerability was consistently rated as good to excellent by both investigator and patients.
Who is Profhilo® Structura suitable for?
In my practice I distinguish two typical ageing profiles for which Profhilo® Structura is particularly suitable:
The "sinkers"
Slim, athletic patients with pronounced volume loss in the cheek area. The cheeks appear hollow or sunken. Here, Profhilo® Structura is injected pre-auricularly to specifically regenerate the lateral fat compartment.
The "saggers"
Patients with tissue laxity and the onset of sagging in the chin and cheeks. Here I combine the pre-auricular injection with a zygomatic application for visible firming and contour improvement.
The treatment at PRECIOUS
Profhilo® Structura is injected with a blunt cannula – with only one entry point per side of the face. This considerably minimises the risk of haematomas and swelling. The recommended treatment cycle comprises two sessions 30 days apart, followed by an individual maintenance therapy.
The result unfolds gradually: firmer skin, more natural volume, a defined chin and jawline – without an over-filled effect.
Would you like to find out whether Profhilo® Structura is right for you?
Book your personal consultation at PRECIOUS in Wiesbaden.

